Studies on the laccases catalyzed oxidation of norbelladine like acetamides

Herein, we study for the first time, the Laccase catalyzed oxidation of Norbelladine like amides 1 and 2. It was determined that the Laccases/ABTS and Laccases alone were able to catalyze the dimerization and trimerization reaction of the amides 1 and 2 in high conversions, respectively. The synthesis of the selectively deuterated substrates D-1 and D-2 and the analysis of their reaction products by HPLC-ESI-TOF MS allowed the determination of the bond (CC or CO) formed between the monomers.