Treatment Planning Optimization in Irreversible Electroporation for Complete Ablation of Variously Sized Cervical Tumors: A Numerical Study

不可逆电穿孔 协议(科学) 烧蚀 电穿孔 分类 医学 计算机科学 肿瘤消融 算法 病理 内科学 生物 生物化学 基因 替代医学
作者
Lujia Ding,Mike Moser,Yigang Luo,Wenjun Zhang,Bing Zhang
出处
期刊:Journal of biomechanical engineering [ASM International]
卷期号:143 (1) 被引量:17
标识
DOI:10.1115/1.4047551
摘要

Abstract Irreversible electroporation (IRE), a relatively new energy-based tumor ablation technology, has shown itself in the last decade to be able to safely ablate tumors with favorable clinical outcomes, yet little work has been done on optimizing the IRE protocol to variously sized tumors. Incomplete tumor ablation has been shown to be the main reason leading to the local recurrence and thus treatment failure. The goal of this study was to develop a general optimization approach to optimize the IRE protocol for cervical tumors in different sizes, while minimizing the damage to normal tissues. This kind of approach can lay a foundation for future personalized treatment of IRE. First, a statistical IRE cervical tumor death model was built using previous data in our group. Then, a multi-objective optimization problem model was built, in which the decision variables are five IRE-setting parameters, namely, the pulse strength (U), the length of active tip (H), the number of pulses delivered in one round between a pair of electrodes (A), the distance between electrodes (D), and the number of electrodes (N). The domains of the decision variables were determined based on the clinical experience. Finally, the problem model was solved by using nondominated sorting genetic algorithms II (NSGA-II) algorithm to give respective optimal protocol for three sizes of cervical tumors. Every protocol was assessed by the evaluation criterion established in the study to show the efficacy in a more straightforward way. The results of the study demonstrate this approach can theoretically provide the optimal IRE protocol for different sizes of tumors and may be generalizable to other types, sizes, and locations of tumors.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
joni发布了新的文献求助20
2秒前
乐乐应助诚心的月光采纳,获得10
2秒前
wbh发布了新的文献求助10
2秒前
yyy发布了新的文献求助10
2秒前
2秒前
taotao发布了新的文献求助10
3秒前
科研通AI5应助5555采纳,获得10
3秒前
牟翎完成签到,获得积分10
5秒前
幻月完成签到,获得积分10
5秒前
冷艳咖啡豆完成签到,获得积分10
5秒前
7秒前
10秒前
雪山飞龙发布了新的文献求助10
11秒前
饼冰饼完成签到,获得积分20
11秒前
suibian完成签到,获得积分10
12秒前
12秒前
旺仔完成签到 ,获得积分10
13秒前
13秒前
13秒前
13秒前
14秒前
15秒前
昏睡的蟠桃应助朴实云朵采纳,获得30
15秒前
36456657应助LCX采纳,获得10
15秒前
123完成签到,获得积分10
17秒前
昏睡的蟠桃应助ZZQ采纳,获得20
17秒前
17秒前
18秒前
7788999发布了新的文献求助10
18秒前
wangyue发布了新的文献求助10
18秒前
19秒前
20秒前
贝贝发布了新的文献求助10
20秒前
科研通AI5应助taotao采纳,获得10
20秒前
20秒前
21秒前
123发布了新的文献求助10
21秒前
费乐巧发布了新的文献求助10
22秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Neuromuscular and Electrodiagnostic Medicine Board Review 1000
こんなに痛いのにどうして「なんでもない」と医者にいわれてしまうのでしょうか 510
The First Nuclear Era: The Life and Times of a Technological Fixer 500
ALUMINUM STANDARDS AND DATA 500
岡本唐貴自伝的回想画集 500
Distinct Aggregation Behaviors and Rheological Responses of Two Terminally Functionalized Polyisoprenes with Different Quadruple Hydrogen Bonding Motifs 450
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3668063
求助须知:如何正确求助?哪些是违规求助? 3226515
关于积分的说明 9769764
捐赠科研通 2936459
什么是DOI,文献DOI怎么找? 1608572
邀请新用户注册赠送积分活动 759665
科研通“疑难数据库(出版商)”最低求助积分说明 735460