作者
Jürgen Wolf,Takashi Seto,Ji‐Youn Han,Noemı́ Reguart,Edward B. Garon,Harry J.M. Groen,Daniel S.W. Tan,Toyoaki Hida,Maja J.A. de Jonge,Sergey Orlov,Egbert F. Smit,Pierre-Jean Souquet,Johan Vansteenkiste,Maximilian J. Hochmair,Enriqueta Felip,Makoto Nishio,Michael Thomas,Kadoaki Ohashi,Ryo Toyozawa,Tobias R. Overbeck,Filippo de Marinis,Tae Min Kim,Eckart Laack,Anna Robeva,Sylvie Le Mouhaër,Maeve Waldron-Lynch,B. Sankaran,O. Alejandro Balbin,Xiaoming Cui,Monica Giovannini,Mikhail Akimov,Rebecca S. Heist
摘要
Among patients with non–small-cell lung cancer (NSCLC), MET exon 14 skipping mutations occur in 3 to 4% and MET amplifications occur in 1 to 6%. Capmatinib, a selective inhibitor of the MET receptor, has shown activity in cancer models with various types of MET activation.