Laminin associated with BMP7 as potential secondary astrocytic glioma fiber differentiation targets.

To investigate the activation of the BMP7 and laminin pathway is associated with glioma cell proliferation and differentiation.We enrolled 65 patients with primary operable glioma. Laminin and BMP7 protein expression and its subcellular localization were studied by immunofluorescence.We detected a higher level of BMP7 expression in glioma tissue in patients with a lower grade of glioma who had a lower eosinophil count. Compared to patients with a higher grade of glioma, we observed a lower level of laminin expression in patients with a lower grade of glioma.Our data indicated a potential link between eosinophil counts and the expression levels of laminin and BMP7 in glioma differentiation.