Chemically or surgically induced thyroid dysfunction altered gut microbiota in rat models

The FASEB JournalVolume 34, Issue 6 p. 8686-8701 RESEARCH ARTICLEFree to Read Chemically or surgically induced thyroid dysfunction altered gut microbiota in rat models Na Rae Shin, Na Rae Shin Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of KoreaSearch for more papers by this authorShambhunath Bose, Shambhunath Bose NosQuest, Seongnam-si, Republic of KoreaSearch for more papers by this authorJing-Hua Wang, Jing-Hua Wang Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of KoreaSearch for more papers by this authorYoung-Do Nam, Young-Do Nam Research Group of Gut Microbiome, Korea Food Research Institute, Wanju-gun, Republic of Korea Department of Food Biotechnology, Korea University of Science and Technology, Wanju, Republic of KoreaSearch for more papers by this authorEun-Ji Song, Eun-Ji Song Research Group of Gut Microbiome, Korea Food Research Institute, Wanju-gun, Republic of Korea Department of Food Biotechnology, Korea University of Science and Technology, Wanju, Republic of KoreaSearch for more papers by this authorDong-Woo Lim, Dong-Woo Lim Department of Pathology, College of Korean Medicine, Dongguk University, Republic of KoreaSearch for more papers by this authorHee-Bok Kim, Hee-Bok Kim Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University, Goyang, Republic of KoreaSearch for more papers by this authorYun-Sung Lim, Yun-Sung Lim Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University, Goyang, Republic of KoreaSearch for more papers by this authorHan Seok Choi, Han Seok Choi Department of Endocrinology, Dongguk University, Goyang, Republic of KoreaSearch for more papers by this authorHojun Kim, Corresponding Author Hojun Kim [email protected] Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of Korea Correspondence Yun-Sung Lim, Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University, Dongguk-ro 32, Goyang, Gyeonggi-do, Republic of Korea. Email: [email protected] Han Seok Choi, Department of Endocrinology, Dongguk University, Dongguk-ro 32, Goyang, Gyeonggi-do, Republic of Korea. Email: [email protected] Hojun Kim, Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of Korea. Email: [email protected]Search for more papers by this author Na Rae Shin, Na Rae Shin Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of KoreaSearch for more papers by this authorShambhunath Bose, Shambhunath Bose NosQuest, Seongnam-si, Republic of KoreaSearch for more papers by this authorJing-Hua Wang, Jing-Hua Wang Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of KoreaSearch for more papers by this authorYoung-Do Nam, Young-Do Nam Research Group of Gut Microbiome, Korea Food Research Institute, Wanju-gun, Republic of Korea Department of Food Biotechnology, Korea University of Science and Technology, Wanju, Republic of KoreaSearch for more papers by this authorEun-Ji Song, Eun-Ji Song Research Group of Gut Microbiome, Korea Food Research Institute, Wanju-gun, Republic of Korea Department of Food Biotechnology, Korea University of Science and Technology, Wanju, Republic of KoreaSearch for more papers by this authorDong-Woo Lim, Dong-Woo Lim Department of Pathology, College of Korean Medicine, Dongguk University, Republic of KoreaSearch for more papers by this authorHee-Bok Kim, Hee-Bok Kim Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University, Goyang, Republic of KoreaSearch for more papers by this authorYun-Sung Lim, Yun-Sung Lim Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University, Goyang, Republic of KoreaSearch for more papers by this authorHan Seok Choi, Han Seok Choi Department of Endocrinology, Dongguk University, Goyang, Republic of KoreaSearch for more papers by this authorHojun Kim, Corresponding Author Hojun Kim [email protected] Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of Korea Correspondence Yun-Sung Lim, Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University, Dongguk-ro 32, Goyang, Gyeonggi-do, Republic of Korea. Email: [email protected] Han Seok Choi, Department of Endocrinology, Dongguk University, Dongguk-ro 32, Goyang, Gyeonggi-do, Republic of Korea. Email: [email protected] Hojun Kim, Department of Rehabilitation Medicine of Korean medicine, Dongguk University, Republic of Korea. Email: [email protected]Search for more papers by this author First published: 01 May 2020 https://doi.org/10.1096/fj.201903091RRCitations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Thyroid hormones are essential for the regulation of energy homeostasis and metabolic processes. However, the relationship between thyroid function and host gut microbial communities is not properly understood. To determine whether and how gut microbiota is associated with thyroid function, metagenomics analysis of the bacterial population in fecal samples of rat models of hyperthyroidism (induced by levothyroxine) and hypothyroidism (induced by propylthiouracil or thyroidectomy) was conducted through 16S rRNA gene sequencing. Our results revealed that all thyroid dysfunction models were definitely established and gut microbial composition varied according to different thyroid functional status. The relative abundance of Ruminococcus was significantly higher in the hyperthyroidism group (HE) vs both the normal and hypothyroidism groups (HO) while S24-7 was significantly higher in the HO group. The population of Prevotellaceae and Prevotella were significantly lower in the HO group vs the normal. Firmicutes and Oscillospira were significantly higher in the SHO (surgery-induced hypothyroidism) group, while Prevotellaceae and Prevotella showed lower abundance in the SHO group than the SHAM group. Present results suggest that thyroid functions may have the potential to influence the profile of gut microbiota and could be used as foundation to investigate interaction mechanism between thyroid and gut microbiome. 5 CONFLICT OF INTEREST The authors do not have any conflict of interest regarding this research or publication. Citing Literature Supporting Information Filename Description fsb220586-sup-0001-FigS1-S5.docxWord document, 890.9 KB Fig S1-S5 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume34, Issue6June 2020Pages 8686-8701 RelatedInformation