Coronary flow velocity reserve predicts adverse prognosis in women with angina and no obstructive coronary artery disease: results from the iPOWER study.

冠状动脉血流储备 动脉 部分流量储备
作者
Jakob Schroder,Marie Mide Michelsen,Naja Dam Mygind,Hannah Elena Suhrs,Kira Bang Bové,Daria Frestad Bechsgaard,Ahmed Aziz,Ida Gustafsson,Jens Kastrup,Eva Prescott
出处
期刊:European Heart Journal [Oxford University Press]
卷期号:42 (3): 228-239 被引量:14
标识
DOI:10.1093/eurheartj/ehaa944
摘要

AIMS Many patients with angina, especially women, do not have obstructive coronary artery disease (CAD) yet have impaired prognosis. We investigated whether routine assessment of coronary microvascular dysfunction (CMD) is feasible and predicts adverse outcome in women with angina and no obstructive CAD. METHODS AND RESULTS After screening 7253, we included 1853 women with angina and no obstructive CAD on angiogram who were free of previous CAD, heart failure, or valvular heart disease in the prospective iPOWER (Improving Diagnosis and Treatment of Women with Angina Pectoris and Microvascular Disease) study. CMD was assessed by Doppler echocardiography in the left anterior descending artery as coronary flow velocity reserve (CFVR). Patients were followed for a composite outcome of cardiovascular death, myocardial infarction (MI), heart failure, stroke, and coronary revascularization. CFVR was obtained in 1681 patients (91%) and the median CFVR was 2.33 (quartiles 1-3: 2.00-2.74). During a median follow-up of 4.5 years, 96 events occurred. In univariate Cox regression, CFVR was associated with the composite outcome {hazard ratio (HR) 1.07 [95% confidence interval (CI) 1.03-1.11] per 0.1 unit decrease in CFVR; P < 0.001}, primarily driven by an increased risk of MI and heart failure. Results remained significant in multivariate analysis [HR 1.05 (95% CI 1.01-1.09) per 0.1 unit decrease in CFVR; P = 0.01]. In exploratory analyses, CFVR was also associated with the risk of repeated hospital admission for angina and all-cause mortality. CONCLUSION Assessment of CFVR by echocardiography is feasible and predictive of adverse outcome in women with angina and no obstructive CAD. Results support a more aggressive preventive management of these patients and underline the need for trials targeting CMD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
科目三应助111采纳,获得10
1秒前
熙欢发布了新的文献求助20
2秒前
LJF发布了新的文献求助10
2秒前
3秒前
李爱国应助Tsui采纳,获得10
4秒前
所所应助chao采纳,获得10
4秒前
Rank发布了新的文献求助10
5秒前
6秒前
6秒前
7秒前
小二郎应助宫冷雁采纳,获得10
8秒前
magicjerry发布了新的文献求助10
9秒前
天天开心发布了新的文献求助10
9秒前
11秒前
11秒前
12秒前
寂寞的诗云完成签到,获得积分10
12秒前
LJF完成签到,获得积分10
12秒前
13秒前
爆米花应助落寞之云采纳,获得10
14秒前
14秒前
CCC完成签到 ,获得积分10
14秒前
14秒前
15秒前
Cassie发布了新的文献求助10
17秒前
17秒前
天天开心完成签到,获得积分10
17秒前
18秒前
yujie发布了新的文献求助200
18秒前
宫冷雁发布了新的文献求助10
18秒前
19秒前
趣多多发布了新的文献求助10
19秒前
19秒前
难过千易发布了新的文献求助10
20秒前
dengyan完成签到,获得积分10
20秒前
思源应助coco采纳,获得10
20秒前
IU冰冰发布了新的文献求助10
21秒前
22秒前
大模型应助Cassie采纳,获得10
24秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975375
求助须知:如何正确求助?哪些是违规求助? 3519700
关于积分的说明 11199305
捐赠科研通 3256034
什么是DOI,文献DOI怎么找? 1798049
邀请新用户注册赠送积分活动 877386
科研通“疑难数据库(出版商)”最低求助积分说明 806305