脂肪生成
生物
细胞器
内质网
脂滴
线粒体
细胞生物学
膜接触部位
脂质代谢
细胞
脂肪组织
脂滴包被蛋白
脂肪细胞
生物化学
膜蛋白
膜
整体膜蛋白
作者
Christophe Alexis Cédric Freyre,Pascal C. Rauher,Christer S. Ejsing,Robin W. Klemm
出处
期刊:Molecular Cell
[Elsevier]
日期:2019-12-01
卷期号:76 (5): 811-825.e14
被引量:149
标识
DOI:10.1016/j.molcel.2019.09.011
摘要
Physical contact between organelles is vital to the function of eukaryotic cells. Lipid droplets (LDs) are dynamic organelles specialized in lipid storage that interact physically with mitochondria in several cell types. The mechanisms coupling these organelles are, however, poorly understood, and the cell-biological function of their interaction remains largely unknown. Here, we discover in adipocytes that the outer mitochondrial membrane protein MIGA2 links mitochondria to LDs. We identify an amphipathic LD-targeting motif and reveal that MIGA2 binds to the membrane proteins VAP-A or VAP-B in the endoplasmic reticulum (ER). We find that in adipocytes MIGA2 is involved in promoting triglyceride (TAG) synthesis from non-lipid precursors. Our data indicate that MIGA2 links reactions of de novo lipogenesis in mitochondria to TAG production in the ER, thereby facilitating efficient lipid storage in LDs. Based on its presence in many tissues, MIGA2 is likely critical for lipid and energy homeostasis in a wide spectrum of cell types.
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