光热治疗
吞噬作用
炎症
材料科学
巨噬细胞
纳米团簇
纳米材料
免疫系统
癌症研究
纳米技术
免疫学
医学
生物
生物化学
体外
作者
Xin Wang,Xiaoyu Wu,Jinbao Qin,Kaichuang Ye,Feili Lai,Bo Li,Guanjie He,Xinwu Lu,Dan J. L. Brett,Ivan P. Parkin
标识
DOI:10.1021/acsami.9b12258
摘要
Inflammatory macrophage (Mφ)-mediated atherosclerosis is a leading cause of mortality and morbidity worldwide. Photothermal therapy (PTT) has been demonstrated as an efficient strategy in killing target cells, and its application in the treatment of inflammation in atherosclerosis is developing. However, the choice of nanomaterials, mechanisms, and side effects are seldom considered. In this study, semiconductor nanomaterials, that is, MoO2 nanoclusters, were synthesized and used for the first time in PTT for inflammatory Mφ-mediated atherosclerosis. Based on cell differential phagocytosis, the optimum amount of MoO2 and treatment time were selected to exert the maximum ablation effect on Mφ and minimal damage on endothelial cells without requiring additional target or selective groups. Moreover, MoO2-based PTT shows an excellent therapeutic effect on atherosclerosis by eliminating Mφ in animal models, with no significant side effects observed. This study explores a new method of nanotechnology and pharmaceutical development by using and optimizing cost-effective metal oxide nanostructures in the treatment of atherosclerosis and motivates further research on minimizing the side effects of related materials.
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