受体
计算生物学
化学
生物物理学
生物
生物化学
作者
Parisa Mollaei,Prakarsh Yadav,Yuyang Wang,Zhonglin Cao,Amir Barati Farimani
标识
DOI:10.1016/j.bpj.2021.11.663
摘要
The G protein-coupled receptors (GPCRs) are membrane proteins with clinical and physiological significance. GPCRs are the target for one-third of the FDA-approved drugs and play a major role in regulation of many biological pathways inside the cells. Understanding features associated with GPCR conformational dynamics is crucial in the development of new therapeutic targets. The grand challenge with the elucidation of the GPCR conformational changes is its intricate and subtle dynamics which varies based on the structure-function relationship.
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