Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis

医学 接收机工作特性 回顾性队列研究 急性呼吸窘迫综合征 机器学习 观察研究 内科学 重症监护医学 人工智能 计算机科学
作者
Manoj V. Maddali,Matthew M. Churpek,Tài Pham,Emanuele Rezoagli,Hanjing Zhuo,Wendi Zhao,June He,Kevin Delucchi,Chunxue Wang,Nancy Wickersham,J. Brennan McNeil,Alejandra Jáuregui,Serena Ke,Kathryn Vessel,Antonio Gomez,Carolyn M. Hendrickson,Kirsten N. Kangelaris,Aartik Sarma,Aleksandra Leligdowicz,Kathleen D. Liu,Michael A. Matthay,Lorraine B. Ware,John G. Laffey,Giacomo Bellani,Carolyn S. Calfee,Pratik Sinha,Fernando Ríos,Frank van Haren,Thierry Sottiaux,Fredy S Lora,Luciano C. P. Azevedo,Pieter Depuydt,Eddy Fan,Guillermo Bugedo,Haibo Qiu,Marcos Gonzalez,Juan Silesky,Vladimír Černý,Jonas Vestergaard Nielsen,Manuel Jibaja,Tài Pham,Hermann Wrigge,Dimitrios Matamis,Jorge Luis Ranero,Seyed Mohammad Reza Hashemian,Pravin Amin,Kevin Clarkson,Giacomo Monti,Kiyoyasu Kurahashi,Asisclo Villagómez,Amine Ali Zeggwagh,Leo M Heunks,Jon Henrik Laake,Jose Emmanuel Palo,Antero Fernandes,Dorel Sandesc,Yaseen M. Arabi,Vesna Bumbasierevic,Nicolas Nin,José A. Lorente,Anders Larsson,Lise Piquilloud,Fekri Abroug,Daniel F. McAuley,Lia McNamee,Javier Hurtado,Ednan K. Bajwa,Gabriel D’Empaire,Guy François,Hektor Sula,Lordian Nunci,Alma Cani,Alan Zazu,Christian Dellera,Carolina S. Insaurralde,Risso V Alejandro,Julio Daldin,Mauricio Vinzio,Ruben O Fernandez,Luis Pablo Cardonnet,Lisandro Roberto Bettini,Mariano Carboni Bisso,Emilio M. Osman,Mariano Setten,Pablo Lovazzano,Javier Alvarez,Veronica Villar,César Milstein,Norberto C. Pozo,Nicolas Grubissich,Gustavo Plotnikow,Daniela N. Vásquez,Santiago Ilutovich,Norberto Tiribelli,Ariel Chena,Carlos A. Pellegrini,María G. Sáenz,Elisa Estenssoro,Matias Brizuela,Hernan Gianinetto,Pablo Gómez,Valeria I. Cerrato,Marco Bezzi,Silvina Borello,Flavia A. Loiacono,Adriana Fernández,Serena Knowles,Claire Reynolds,Deborah Inskip,Jennene Miller,Jing Kong,Christina Whitehead,Shailesh Bihari,Aylin Seven,Amanda Krstevski,Helen Rodgers,Rebecca T. Millar,Toni McKenna,Irene M Bailey,Gabrielle C Hanlon,Anders Åneman,Joan Lynch,Raman Azad,John Neal,Paul W. Woods,Brigit Roberts,Mark Kol,Helen S. Wong,Katharina Riss,Thomas Staudinger,Xavier Wittebole,Caroline Berghe,Pierre Bulpa,Alain Dive,Rik Verstraete,Herve Lebbinck,Pieter Depuydt,Joris Vermassen,Philippe Meersseman,Helga Ceunen,Jonas I Rosa,Daniel O. Beraldo,Claudio Piras,Adenilton M R Ampinelli,Antônio Paulo Nassar,Sergio Mataloun,Marcelo Moock,Marlus M. Thompson,Claudio H. Gonçalves,Ana Carolina Peçanha Antônio,Aline Maria Ascoli,Rodrigo Biondi,Danielle C. Fontenele,Danielle Nobrega,Vanessa M. Sales,Suresh Shindhe,Dk Maizatul Aiman B Pg Hj Ismail,John G. Laffey,François Beloncle,Kyle G. Davies,Rob Cirone,Venika Manoharan,Mehvish Ismail,Ewan C. Goligher,Mandeep Jassal,Erin Nishikawa,Areej Javeed,Gerard Curley,Nuttapol Rittayamai,Matteo Parotto,Niall D. Ferguson,Sangeeta Mehta,Jenny Knoll,Antoine Pronovost,Sergio Canestrini,Alejandro Bruhn,Patricio García,Felipe Aliaga,Pamela A. 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Trinder,Samantha J Hagan,Matt P. Wise,Jade Cole,Caroline Macfie,Anna T Dowling,Javier Hurtado,Javier Hurtado,Edgardo Nuñez,Gustavo Pittini,Ruben Rodriguez,María C. Imperio,Cristina Santos,Ana Graciela França,Alejandro Ebeid,Alberto Deicas,Carolina Serra,Aditya Uppalapati,Ghassan Kamel,Valerie Banner‐Goodspeed,Jeremy R. Beitler,Satyanarayana Reddy Mukkera,Shreedhar Kulkarni,Jarone Lee,Tomaž Mesar,John O. Shinn,Dina Gomaa,Christopher Tainter,Tomaž Mesar,R. Adams Cowley,Dale J. Yeatts,Jessica Warren,Michael J. Lanspa,R. Miller,Colin K. Grissom,Samuel M. Brown,Philippe R. Bauer,Ryan J. Gosselin,Barrett T. Kitch,Jason Cohen,Scott Beegle,Renaud Gueret,Aiman Tulaimat,Shazia Choudry,William S. Stigler,Hitesh Batra,Nidhi G. Huff,Keith Lamb,Trevor W Oetting,Nicholas M Mohr,Claine Judy,Shigeki Saito,Fayez M. Kheir,A Schlichting,Angela Delsing,Mary Elmasri,D.R. Crouch,Dina Ismail,Thomas C Blakeman,Kyle R. Dreyer,Dina Gomaa,Rebecca M. Baron,Carolina Quintana Grijalba,Peter C. Hou,Raghu R. Seethala,Imo Aisiku,Galen Henderson,György Frendl,Sen-Kuang Hou,Robert L. Owens,Ashley Schomer,Vesna Bumbaširević,Bojan Jovanović,Maja Šurbatović,Milić Veljović
出处
期刊:The Lancet Respiratory Medicine [Elsevier]
卷期号:10 (4): 367-377 被引量:96
标识
DOI:10.1016/s2213-2600(21)00461-6
摘要

Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven individual cohorts. To facilitate bedside identification of subphenotypes, clinical classifier models using readily available clinical variables have been described in four randomised controlled trials. We aimed to assess the performance of these models in observational cohorts of ARDS.
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