细胞骨架
伤口愈合
生物
细胞生物学
肌动蛋白细胞骨架
肌动蛋白
透视图(图形)
生物化学
细胞
遗传学
人工智能
计算机科学
作者
Parinaz Ahangar,Xanthe L. Strudwick,Allison J. Cowin
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2022-01-24
卷期号:14 (8): a041235-a041235
被引量:5
标识
DOI:10.1101/cshperspect.a041235
摘要
Wound healing requires a complex cascade of highly controlled and conserved cellular and molecular processes. These involve numerous cell types and extracellular matrix molecules regulated by the actin cytoskeleton. This microscopic network of filaments is present within the cytoplasm of all cells and provides the shape and mechanical support required for cell movement and proliferation. Here, an overview of the processes of wound healing are described from the perspective of the cell in relation to the actin cytoskeleton. Key points of discussion include the role of actin, its binding proteins, signaling pathways, and events that play significant roles in the phases of wound healing. The identification of cytoskeletal targets that can be used to manipulate and improve wound healing is included as an emerging area of focus that may inform future therapeutic approaches to improve healing of complex wounds.
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