AB0993 INDICATORS OF BONE MINERAL DENSITY IN ELDERLY AND SENILE MALE PATIENTS WITH OSTEOARTHRITIS OF THE KNEE JOINT, DEPENDING ON THE STATE OF THE MUSCULAR APPARATUS

Objectives To evaluate bone mineral density (BMD) indicators in elderly and senile male patients with osteoarthritis (OA) of the knee joint, depending on the state of the muscular apparatus. Methods The study included 32 patients with an established diagnosis of knee joint OA. The average age of patients was 68.7 (66.1; 70.3) years. The diagnosis of knee joint OA was established according to the diagnostic criteria of the American College of Rheumatology (ACR, 1991). For comparative analysis, all patients were divided into 3 groups depending on the state of the muscular apparatus (EWGSOP, 2010: muscle mass was assessed by multispiral computed tomography, muscle strength was measured using a wrist dynamometer, muscle function was examined using a battery of short tests): 1st – 9 patients without sarcopenia, 2nd - 11 patients with presarcopenia and 3rd - 12 patients with sarcopenia. BMD was assessed by two-energy X-ray absorptiometry in the neck and proximal femur as a whole and in the lumbar spine. Results Osteopenic syndrome in the study cohort was diagnosed in 23 (71.9%) patients: osteopenia - in 19 (59.4%) patients, osteoporosis – in 4 (12.5%). Normal BMD values were observed in 9 (28.1%) patients. Osteopenic syndrome was detected in patients with sarcopenia significantly more often than in patients without sarcopenia (p>0.05) and with presarcopenia (p=0.05). Thus, in the group of patients without sarcopenia, normal BMD indicators were noted in 6 (18.8%) patients, OPe – in 3 (9.4%), no cases of OP were detected. In patients with presarcopenia, normal BMD indicators were determined in 3 (9.4%) patients, OPe - in 8 (25%) patients, no cases of OP were also detected. In patients with sarcopenia, normal BMD indicators were not registered, OPS was detected in 12 (37.5%) patients, while OPe – in 8 (25.0%) and OP – in 4 (12.5%). BMD in patients with sarcopenia in the neck and proximal femur as a whole were statistically significantly lower than in patients without sarcopenia and with presarcopenia (p<0.050). The BMD in the femoral neck in patients with sarcopenia was 0.908 [0.817; 0.977] g/cm2, which corresponds to -0.95 [-1.35; 0.425] CO according to the T-criterion, while in the groups of patients without sarcopenia and with presarcopenia, statistically significantly higher BMD values were recorded: 0.998 [0.935; 1.09] g/cm2 and 0.995 [0.94; 1.04] g/cm2 (p=0.009 and p=0.027), which corresponds to -0.30 [-0.80; 0.225] and -0.30 [-0.70; 0] CO according to the T-criterion (p= 0.013 and p=0.024), respectively. When comparing the BMD and T-test in the lumbar spine, there were no statistically significant differences in the studied groups of patients. Conclusion Sarcopenia is associated with low BMD in the neck and proximal femur in general in elderly and senile male patients with knee joint OA. Disclosure of Interests None declared