上睑下垂
免疫疗法
癌症免疫疗法
癌症研究
癌症
癌细胞
化学
免疫系统
线粒体
程序性细胞死亡
生物
细胞生物学
细胞凋亡
医学
免疫学
生物化学
内科学
作者
Pan Zheng,Binbin Ding,Guo‐Qing Zhu,Chunxia Li,Jun Lin
标识
DOI:10.1002/anie.202204904
摘要
Pyroptosis provides a new direction and broad prospects for cancer immunotherapy. However, the development of a nanoplatform as a pyroptosis inducer is limited, and the discovery of a new type of nano-pyroptosis inducer for cancer immunotherapy is still imminent. Herein, biodegradable Ca2+ nanomodulators (CaNMs) are prepared as pyroptosis inducers for cancer immunotherapy via mitochondrial Ca2+ overload. The obtained CaNMs can decompose under low pH to release Ca2+ and curcumin, leading to a sudden surge in mitochondrial Ca2+ ions, eventually resulting in pyroptosis. We not only confirm the occurrence of mitochondrial Ca2+ overload-triggered pyroptosis for the first time but also reveal the robust immune responses via CaNMs, along with remarkably suppressing tumor proliferation and lung metastasis. This work will provide new strategies and inspiration for pyroptosis-mediated cancer treatments, greatly contributing to the further development of Ca2+ nanomodulators.
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