光动力疗法
体内
荧光
化学
癌症
体外
癌症研究
生物标志物
生物物理学
荧光寿命成像显微镜
癌细胞
细胞凋亡
转移
生物
医学
生物化学
内科学
光学
物理
生物技术
有机化学
作者
Feiyan Liu,Dongrong Zhu,Yin Li,Min Kong,Yalin Li,Jian‐Guang Luo,Lingyi Kong
标识
DOI:10.1016/j.snb.2022.131838
摘要
The excessive expression of γ-glutamyltranspeptidase (GGT) is known to be closely associated with the progression, invasion and metastasis of malignant tumors, enabling GGT to be a cancer-related biomarker for cancer diagnosis. The development of the multifunctional fluorescent probe that combines GGT measurement and photodynamic therapy (PDT) into a single platform possesses exciting prospect for concurrent tumor diagnosis and treatment. In this study, we designed a new near-infrared (NIR) fluorescent probe (CyI-Glu) with therapeutic function which could realize the integration of fluorescence endogenous GGT visualization for tumor diagnosis and NIR imaging-guided tumor photodynamic therapy. CyI-Glu manifested a significant turn-on NIR fluorescence (718 nm) in response to GGT, which made it favorable for monitoring GGT activity with high selectivity and sensitivity (0.014 U/L) in vitro and in vivo. Furthermore, this GGT-responsive probe possessed improved ROS generation capacity for tumor cell apoptosis and tumor growth inhibition under NIR light irradiation. Collectively, the multifunctional fluorescent probe CyI-Glu with complementary advantages demonstrates significant potential for the diagnosis and treatment of tumors in complex organisms.
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