德纳姆
睡眠剥夺对认知功能的影响
认知
甲基化
认知测验
载脂蛋白E
DNA甲基化
CpG站点
神经心理学测验
心理学
神经心理学
肿瘤科
内科学
遗传学
生物
医学
神经科学
疾病
基因
基因表达
作者
Botong Shen,Dena Hernandez,Kumaraswamynaidu Chitrala,Marie Fanelli Kuczmarski,Nicole Noren Hooten,Natasha L. Pacheco,Nicolle A. Mode,Alan B. Zonderman,Ngozi Ezike,Michele K. Evans
标识
DOI:10.1016/j.neurobiolaging.2022.03.010
摘要
Apolipoprotein (APOE) ε4 allele is a strong risk factor for Alzheimer's disease (AD) and cognitive decline. Epigenetic modifications such as DNA methylation (DNAm) play a central role in cognition. This study sought to identify DNAm sites in the APOE genomic region associated with cognitive performance in a racially diverse middle-aged cohort (n = 411). Cognitive performance was measured by 11 standard neuropsychological tests. Two CpG sites were associated with the Card Rotation and Benton Visual Retention cognitive tests. The methylation level of the CpG site cg00397545 was associated with Card Rotation Test score (p = 0.000177) and a novel CpG site cg10178308 was associated with Benton Visual Retention Test score (p = 0.000084). Significant associations were observed among the dietary inflammatory index, which reflects the inflammatory potential of the diet, cognitive performance and the methylation level of several CpG sites. Our results indicate that DNAm in the APOE genomic area is correlated with cognitive performance and may presage cognitive decline.
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