海马结构
海马体
情景记忆
神经科学
光遗传学
均方预测误差
心理学
助记符
单变量
认知心理学
计算机科学
认知
机器学习
多元统计
作者
Alyssa H. Sinclair,Grace M. Manalili,Iva K. Brunec,R. Alison Adcock,Morgan D. Barense
标识
DOI:10.1073/pnas.2117625118
摘要
Significance Our brains draw on memories to predict the future; when our predictions are incorrect, we must update our memories to improve future predictions. Past studies have demonstrated that the hippocampus signals prediction error (i.e., surprise) but have not linked this neural signal to memory updating. Here, we uncover this missing connection. We show that mnemonic prediction errors change the role of the hippocampus, reversing the relationship between hippocampal activation and memory outcomes. We examine the mechanisms of this shift in neural processing, showing that prediction errors disrupt the temporal continuity of hippocampal patterns. We propose that prediction errors disrupt sustained representations and enable memory updating. Our findings bear implications for improving education, understanding eyewitness memory distortion, and treating pathological memories.
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