小干扰RNA
药物输送
弧(几何)
药品
靶向给药
抗体
药物开发
毒品携带者
抗体-药物偶联物
结合
医学
化学
药理学
纳米技术
免疫学
核糖核酸
工程类
单克隆抗体
材料科学
数学
生物化学
数学分析
机械工程
基因
作者
Weiran Cao,Rui Li,Xing Pei,Mei-Hong Chai,Lu Sun,Yuanyu Huang,Jiancheng Wang,Stefan Barth,Fei Yu,Huining He
标识
DOI:10.1016/j.medidd.2022.100128
摘要
Antibody–drug conjugates (ADC) utilizing the targeting properties of antibodies and therapeutic effects of drugs have emerged a rapid development in recent years. However, the relatively low drug loading capacity of ADC systems commonly results in failure in delivering enough chemical drugs to the desired areas given a safe antibody dose, therefore the therapeutic efficacy of ADC systems is restricted. With the FDA approval of four siRNA drugs, patisiran, givosiran, lumasiran and inclisiran, the development of siRNAs has regained huge attention of researchers, where the design of delivery system for siRNAs is the key issue for further clinical applications. Inspired by the concept of ADC, the antibody–siRNA conjugates (ARC) have emerged as a potential vehicle for targeted siRNA drug delivery, with the ability to overcome the current obstacles in siRNA delivery. In this review, we summarized the efforts in the development of antibody–siRNA conjugates and hope to provide a basic view for researchers who are interested in this field.
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