自愈水凝胶
化学
药物输送
点击化学
连接器
PEG比率
生物材料
四嗪
细胞毒性
高分子化学
生物物理学
化学工程
组合化学
有机化学
生物化学
体外
操作系统
财务
计算机科学
经济
生物
工程类
作者
Trung Thang Vu,Muhammad Gulfam,Sung‐Han Jo,Sang-Hyug Park,Kwon Taek Lim
标识
DOI:10.1016/j.carbpol.2021.118964
摘要
In this work, novel injectable and reduction-responsive hydrogels were successfully prepared via inverse electron demand Diels-Alder reaction between alginate-norbornene and a water-soluble PEG based disulfide cross-linker. The reduction-responsive cross-linker was designed to contain a PEG chain within two disulfide linkages, and two terminal tetrazine groups. The resulting hydrogels possessed high swelling ratios, porous morphology, excellent drug loading efficiency (~92%), and suitable mechanical properties. The drug release experiments demonstrated that the hydrogels released more than 90% of the encapsulated doxorubicin (DOX) in the presence of 10 mM glutathione while a minimal DOX release (<25%) was measured in physiological buffer (PBS, pH = 7.4) after 11 d. The cross-linker and hydrogels did not exhibit any apparent cytotoxicity to fibroblast cells. In contrast, DOX-loaded hydrogels induced anti-tumor activity against cancer cells. The injectable and reduction-responsive hydrogels hold great potential as a biomaterial for stimuli responsive drug delivery applications.
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