甲基转移酶
甲基化
生物
核受体
表观遗传学
受体
转录因子
DNA甲基化
去甲基化
调节器
细胞生物学
生物信息学
遗传学
基因表达
基因
作者
Lucie Malbeteau,Ha Thuy Pham,Louisane Eve,Michael R. Stallcup,Coralie Poulard,Muriel Le Romancer
出处
期刊:Endocrine Reviews
[The Endocrine Society]
日期:2021-05-05
卷期号:43 (1): 160-197
被引量:17
标识
DOI:10.1210/endrev/bnab014
摘要
Abstract Steroid receptors (SRs) are members of the nuclear hormonal receptor family, many of which are transcription factors regulated by ligand binding. SRs regulate various human physiological functions essential for maintenance of vital biological pathways, including development, reproduction, and metabolic homeostasis. In addition, aberrant expression of SRs or dysregulation of their signaling has been observed in a wide variety of pathologies. SR activity is tightly and finely controlled by post-translational modifications (PTMs) targeting the receptors and/or their coregulators. Whereas major attention has been focused on phosphorylation, growing evidence shows that methylation is also an important regulator of SRs. Interestingly, the protein methyltransferases depositing methyl marks are involved in many functions, from development to adult life. They have also been associated with pathologies such as inflammation, as well as cardiovascular and neuronal disorders, and cancer. This article provides an overview of SR methylation/demethylation events, along with their functional effects and biological consequences. An in-depth understanding of the landscape of these methylation events could provide new information on SR regulation in physiology, as well as promising perspectives for the development of new therapeutic strategies, illustrated by the specific inhibitors of protein methyltransferases that are currently available.
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