顺铂
丙二醛
氧化应激
肾毒性
超氧化物歧化酶
药理学
肌酐
多糖
肿瘤坏死因子α
化疗
化学
血尿素氮
医学
生物化学
内分泌学
内科学
毒性
作者
Mingzi Ouyang,Lizhu Lin,Wen-jiao Lv,Qian Zuo,Zhuo Liu,Jieshan Guan,Shu-tang Wang,Lingling Sun,Hanrui Chen,Zhiwei Xiao
标识
DOI:10.1016/j.ijbiomac.2016.04.084
摘要
The weight-loaded swimming capability, tumor growth, survival time and biochemical markers of Ganoderma lucidum polysaccharides (GLPs) in a chemotherapy-related fatigue mouse model were tested in the present study. The results showed that the middle-dose GLPs (GLP-M) and the high-dose GLPs (GLP-H) could increase the exhausting swimming time, which was observed to decrease in the cisplatin control group(PCG) and the tumor control group (TCG).The GLP-M and the GLP-H had reduced serum levels of tumor necrosis factor-αand interleukin-6, which were up-regulated by cisplatin. Cisplatin and the presence of tumor significantly enhanced the malondialdehyde (MDA) content and inhibited the activity of superoxide dismutase (SOD) in the muscle. Administration of GLPs at a high dose decreased the levels of MDA and up-regulated the SOD activity. The high-dose GLPs+cisplatin group presented a decreased tendency of tumor volume and a lower tumor weight compared with PCG. Moreover, the mice in the GLP-M and GLP-H groups had longer survival times compared with the mice in the TCG and PCG.The levels of creatinine and serum blood urea nitrogen, which are up-regulated by cisplatin, were significantly reduced by GLP-M and GLP-H. Therefore, these results suggest that GLPs might improve chemotherapy-related fatigue via regulation of inflammatory responses, oxidative stress and reduction of nephrotoxicity.
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