凝集素
痴呆
医学
认知障碍
神经毒性
疾病
内科学
认知
淀粉样蛋白(真菌学)
相关性
病理
精神科
生物
毒性
生物化学
细胞凋亡
几何学
数学
作者
Artor Niccoli Asabella,Marilena Ruggeri,Domenico Rubini,Lorenzo Polimeno,Cristina Spinelli,Marella Polito,M Pennelli,Corinna Altini,Maria Montes de Oca,Giovanni Defazio,Giuseppe Rubini
出处
期刊:Recenti progressi in medicina
日期:2013-07-01
卷期号:104 (7-8): 393-7
被引量:1
摘要
Cognitive impairment is frequent in patients with Parkinson's disease (PD), and can range from mild deterioration to dementia. Recently a contribution of Alzheimer's disease for the cognitive dysfunction in PD has been proposed, whereas the presence of tau protein and amyloid was recognized. Clusterin/ApoJ is a protein involved in the deposition of beta-amyloid and in its neurotoxicity. In this study we aimed to investigate the clusterin/ApoJ's plasma levels in patients with PD to assess its potential role in fisiopathogenetic cognitive impairment.
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