细胞生物学
细胞粘附分子
细胞粘附
整合素
神经细胞粘附分子
细胞周期蛋白
生物
细胞周期蛋白
细胞间粘附分子
细胞周期蛋白D
化学
细胞
细胞周期
生物化学
作者
Zhao‐Jun Liu,Yoshiya Tanaka,Shinichiro Mine,Akio Morinobu,Hideo Yagita,Ko Okumura,Tadatsugu Taniguchi,Hirohei Yamamura,Yasuhiro Minami
出处
期刊:Blood
[American Society of Hematology]
日期:1998-12-15
卷期号:92 (12): 4700-4711
被引量:16
标识
DOI:10.1182/blood.v92.12.4700
摘要
Very late antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) are a pair of adhesion molecules mediating cell-cell interaction. The binding activity of each depends on its surface expression, yet integrin activity can also be modulated through inside-out signaling. However, the specific intracellular molecules involved in modulating integrin VLA-4 activation via inside-out signaling or in regulating VCAM-1 expression are poorly understood. We show here that constitutive coexpression of cyclin C and c-Myc in hematopoietic BAF-B03 cells induces homotypic cell adhesion, which results from enhanced VLA-4 ligand-binding activity and induced expression of VCAM-1. Furthermore, regulation of cell adhesion appears to be a feature unique to cyclin C, but not other G1 cyclins, E and D3, and its regulatory function is independent of CDK8 kinase activity. Our results provide a novel role for cyclin C and c-Myc in the regulation of cell adhesion through distinct mechanisms.
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