Catheter-directed thrombolytic therapy with use of reteplase and urokinase for the treatment of acute deep venous thrombosis of lower extremity:an observation of clinical results

Objective To investigate the clinical efficacy and adverse reactions of catheter-directed thrombolytic therapy with use of reteplase(rPA) and urokinase(UK) in treating acute deep venous thrombosis(ADVT) of lower extremity.Methods During the period from Dec.2008 to May 2012,a total of 40 patients with ADVT were admitted to author’s hospital.The patients were randomly and equally divided into tow groups with 20 patients in each group.Catheter-directed thrombolytic therapy was carried out in all patients by using rPA 20 MU for patients in group A and UK(5-6) × 105 u for patients in group B.Additional anticoagulants and anti-platelet drugs were employed at the same time.Clinical efficacy,allergic reaction and the complication of bleeding were recorded.The results were analyzed.Results The total response rate of group A(rPA) and group B(UK) was 100% and 95% respectively.The difference in the response rate between the two groups was not statistically significant(P 0.05).Compared with UK,the thrombolysis effect of rPA acted instantly.The time of effectiveness of rPA is satisfactorily longer than that of UK.No significant difference in the occurrence of allergic reaction and bleeding existed between the two groups(P 0.05).Conclusion Both rPA and UK are safe thrombolytics with reliable effect in treating acute deep venous thrombosis.The rPA acts its thrombolytic effect promptly and carries a longer time of effectiveness than UK does.