[The association between polymorphism of the serotonin 2A, 2C receptor genes and obstructive sleep apnea-hypopnea syndrome in Han population].

基因型 阻塞性睡眠呼吸暂停 内科学 等位基因 多导睡眠图 内分泌学 多态性(计算机科学) 呼吸不足 等位基因频率 基因型频率 血清素 睡眠呼吸暂停 生物 受体 医学 遗传学 基因 呼吸暂停
作者
Jianyong Zhu,Ke Hu,Zuo-Sheng Ma,Dan Liu
标识
摘要

To investigate the association between polymorphisms of the serotonin 2A, 2C receptor genes and obstructive sleep apnea-hypopnea syndrome (OSAHS), and therefore to explore the genotypes related to OSAHS.The T102C and A1438G polymorphisms of the serotonin 2A receptor genes and the G796C polymorphisms of the serotonin 2C receptor genes were identified by polymerase chain reaction-restricted fragment length polymorphism assay in 119 unrelated subjects (including 65 OSAHS patients and 54 normal controls) of "Han" population of China. The genotype distribution and the allele frequencies of the polymorphisms were compared between the OSAHS group and the control group. The effects of polymorphisms in the OSAHS group on parameters of polysomnography and indexes correlated with obesity were analyzed.There was no significant difference in genotype distribution and allele frequencies of the T102C polymorphisms of the serotonin 2A receptor genes between the two groups; the frequencies of TT/TC/CC genotype and T/C allele were 27.7% (18/65), 46.2% (30/65), 26.1% (17/65), 50.8% (66/130) and 49.2% (64/130), respectively in the OSAHS group; but were 27.8% (15/54), 51.8% (28/54), 20.4% (11/54), 53.7% (58/108) and 46.3% (50/108), respectively in the control group (chi(2) = 0.616 and 0.203, respectively, P > 0.05). The G796C polymorphisms of the serotonin 2C receptor genes were as follows: the frequencies of male's G/C allele, female's GG/GC genotype and G/C allele were 88.9% (48/54), 11.1% (6/54), 63.6% (7/11), 36.4% (4/11), 81.8% (18/22) and 18.2% (4/22), respectively in the OSAHS group; but were 90.5% (38/42), 9.5% (4/42), 66.7% (8/12), 33.3% (4/12), 83.3% (20/24) and 16.7% (4/24), respectively in the control group (chi(2) = 0.007, 0.002 and 0.064, respectively, P > 0.05). The frequencies of AA genotype and A allele in the A1438G polymorphisms of the serotonin 2A receptor genes in the OSAHS group [63.1% (41/65) and 74.6% (97/130), respectively] were significantly higher than those of the control one [27.8% (15/54) and 40.7% (44/108), respectively; chi(2) = 18.779 and 28.035, respectively, P < 0.01]. The OSAHS patients with AA genotype had higher obstructive apnea-hypopnea index (OAHI) and longest apnea time (LAT) than those with AG/GG genotype [OAHI were (40 +/- 9)/h, (25 +/- 9)/h and (20 +/- 11)/h, respectively, t = 6.674 and 7.753, respectively, P < 0.05; LAT were (94 +/- 10) s, (88 +/- 9) s and (75 +/- 12) s, respectively, t = 3.278 and 5.682, respectively, P < 0.05]. The lowest saturation of blood oxygen in patients with AA genotype was significantly lower than that in patients with AG/GG genotype [(69 +/- 12)%, (78 +/- 10)% and (80 +/- 9)%, respectively, t = 4.025 and 4.153, respectively, P < 0.05]. There was no significant difference in body mass index [(26.9 +/- 2.8) kg/m(2), (25.2 +/- 2.7) kg/m(2) and (26.0 +/- 3.7) kg/m(2), respectively], neck circumference [(43.3 +/- 2.7) cm, (42.6 +/- 1.8) cm and (42.8 +/- 2.1) cm, respectively] and waist/hip rate (0.89 +/- 0.12), (0.92 +/- 0.11) and (0.90 +/- 0.09), respectively, F = 0.859, 1.296 and 1.078, respectively, P > 0.05).The T102C polymorphisms of the serotonin 2A receptor gene and the G796C polymorphisms of the serotonin 2C receptor gene may be not associated with OSAHS in subjects of "Han" population of China. The 1438 AA genotype of the serotonin 2A receptor gene may be involved in OSAHS, and the A allele may be an important candidate gene for OSAHS.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
平常的可乐完成签到 ,获得积分10
刚刚
深情安青应助momo采纳,获得10
1秒前
852应助王汉韬采纳,获得10
1秒前
Anmaterchem1完成签到,获得积分10
2秒前
潘善若发布了新的文献求助10
2秒前
西西完成签到,获得积分10
5秒前
乐乐应助潘善若采纳,获得10
7秒前
8秒前
量子星尘发布了新的文献求助10
8秒前
小小完成签到,获得积分10
8秒前
西瓜汁完成签到,获得积分10
9秒前
向日葵完成签到,获得积分10
10秒前
10秒前
11秒前
11秒前
11秒前
12秒前
王汉韬发布了新的文献求助10
13秒前
13秒前
15秒前
鸢也完成签到,获得积分10
15秒前
16秒前
110发布了新的文献求助10
17秒前
18秒前
露露发布了新的文献求助10
18秒前
坚定路人完成签到,获得积分10
19秒前
潘善若发布了新的文献求助10
20秒前
SciGPT应助沈清酌采纳,获得10
21秒前
22秒前
22秒前
23秒前
24秒前
科研通AI2S应助科研通管家采纳,获得10
26秒前
天天快乐应助科研通管家采纳,获得10
26秒前
英俊的铭应助科研通管家采纳,获得10
26秒前
英俊的铭应助科研通管家采纳,获得10
26秒前
赘婿应助科研通管家采纳,获得10
26秒前
隐形曼青应助Lili采纳,获得10
26秒前
隐形曼青应助科研通管家采纳,获得10
26秒前
SYLH应助科研通管家采纳,获得10
26秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989297
求助须知:如何正确求助?哪些是违规求助? 3531418
关于积分的说明 11253893
捐赠科研通 3270097
什么是DOI,文献DOI怎么找? 1804884
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809158