Influences of Bushen Xingnao Decoction on expression of vascular endothelial growth factor, IL-1β and tumor necrosis factor-α in vascular dementia rats.

To observe influences of Bushen Xingnao Decoction (BSXND) on expression of vascular endothelial growth factor (VEGF), IL-1ββ and tumor necrosis factor-α (TNF-α) in brain tissues and serum level of vascular dementia rats and to investigate neuroprotective mechanism of BSXND for vascular dementia. Wistar rats were randomly divided into normal group (N group), sham operation group (S group), dementia model group (M group) and Bushen Xingnao decoction treatment group (MT group). After the model was successfully established, 2, 4, 6 weeks were regarded as observation point. Expressions of VEGF, IL-1β and TNF-α in serum and brain of rat brain were measured by enzyme linked immunosorbent assay. The expressions of IL-1β and TNF-α in MT group were lower than those in M group (P&< 0.05), the expression of VEGF in MT group was higher than that in M group (P&< 0.05); the expressions of VEGF, IL-1β and TNF-α in MT and M groups were higher than those in N and S groups (P&<0.01). BSXND can reduce the levels of IL-1β and TNF-α in brain tissues and serum of vascular dementia rats and increase the expression of VEGF. BSXND can play cerebral protective role by suppressing the neuroinflammation response of vascular dementia rats and enhancing vascular repair.