视网膜
内丛状层
神经科学
无长突细胞
生物
视网膜
视网膜波
神经递质
细胞生物学
抑制性突触后电位
神经节
γ-氨基丁酸
巨大视网膜神经节细胞
神经传递
视网膜神经节细胞
视神经
中枢神经系统
受体
生物化学
出处
期刊:PubMed
日期:1998-01-01
卷期号:5 (2-3): 269-78
被引量:14
摘要
Gamma-aminobutyric acid (GABA) acts as an inhibitory neurotransmitter in the mature vertebrate retina, where it is localized predominantly in amacrine cells, and to a lesser extent in other cell types. During development, GABA is expressed transiently in additional cells, including retinal ganglion cells and horizontal cells. Elements of the GABA system, including GABA uptake and release mechanisms and GABA receptors, are also expressed early in retinal development, well in advance of the onset of visual function. The GABA transporter is a major component of the GABA system in the mature retina, and is most likely responsible for GABA release early in development, prior to the establishment of vesicular synaptic transmission. GABA, produced by amacrine cells and retinal ganglion cells, may serve a developmental role in the establishment of circuitry in the retinal inner plexiform layer and may also be involved in the formation of appropriate central connections by retinal ganglion cell axons.
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