普罗弗拉文
吖啶黄素
化学
顺铂
细胞毒性
组合化学
细胞毒性T细胞
抗菌剂
生物化学
体外
生物
化疗
有机化学
遗传学
DNA
作者
Danica Sabolová,Pavol Kristián,Mária Kožurková
摘要
Abstract Proflavine derivatives are extremely interesting chemotherapeutic agents, which have shown promising pharmaceutical potential due to their wide range of biological activities. This review summarizes the current state of research into the anticancer, antimicrobial, antimalarial and antileishmanial properties of these attractive compounds. Our attention has focused on new classes of proflavine conjugates, which display significant levels of anticancer activity. Highly promising cytotoxic properties have been identified in proflavine conjugates with imidazolidinones, ureas and thioureas. In particular, proflavine‐dialkyldithioureas displayed substantial cytotoxic effect against the human leukemia HL‐60 cells with IC 50 values from 7.2 to 34.0 μ m . As well, palladium complexes with proflavine ligand have important biologic activity. The LC 50 values of these complexes were significantly lower than that of cisplatin against the SK‐BR‐3 cell line.
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