ATP柠檬酸裂解酶
裂解酶
化学
阻塞（统计）
天然产物
行动方式
生物化学
酶
立体化学
计算生物学
组合化学
生物
柠檬酸合酶
计算机科学
计算机网络
作者
Zhangshuang Deng,Nai-Kei Wong,Zhiyong Guo,Kun Zou,Youli Xiao,Yiqing Zhou
摘要
Natural-product macrolide 10,11-dehydrocurvularin (DCV) was revealed to be a potent irreversible inhibitor of ATP-citrate lyase (ACLY) via classical chemoproteomic profiling, which mechanistically illuminates the anti-cancer mode of action of DCV and its analogues.
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