蜗牛
上皮-间质转换
泛素
主调节器
癌症研究
乳腺癌
调节器
癌细胞
细胞生物学
化学
生物
癌症
下调和上调
基因
转录因子
遗传学
生物化学
生态学
作者
Yue Jin,Yu Zhang,Boyuan Li,Jing Zhang,Zhiwen Dong,Xin Hu,Youzhong Wan
标识
DOI:10.1016/j.ijbiomac.2018.11.269
摘要
Migration and invasion of cancer cells are greatly increased during epithelial to mesenchymal transition (EMT). Depletion of TRIM21 promotes the migration and invasion of MCF7 and T47D cells, and changes the expression of genes that regulate EMT. TRIM21 interacts with Snail, a master regulator of EMT. Overexpression of TRIM21 leads to increased ubiquitination and proteosomal degradation of Snail, while depletion of TRIM21 decreases the ubiquitination of Snail. Importantly, depletion of Snail suppresses the increased migration and invasion of MCF7 and T47D cells promoted by depletion of TRIM21. High-level expression of TRIM21 is associated with longer overall survival in breast cancer. Together, our study demonstrates that TRIM21 modulates EMT by mediating the stability of Snail in breast cancer cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI