神经科学
海马体
海马结构
静息状态功能磁共振成像
功能连接
动态功能连接
心理学
计算机科学
作者
Qi Zhong,Huaze Xu,Jian Qin,Ling‐Li Zeng,Dewen Hu,Hui Shen
出处
期刊:Brain Research
[Elsevier]
日期:2019-07-01
卷期号:1715: 165-175
被引量:29
标识
DOI:10.1016/j.brainres.2019.03.023
摘要
The hippocampus consists of functionally and structurally heterogeneous regions that are involved in multiple functions such as learning and memory. Previous studies on connectivity-based functional subdivisions of the hippocampus, however, overlooked the dynamic nature of resting-state functional connectivity (FC). In this study, we selected 50 subjects with the lowest head motion from the Human Connectome Project dataset and performed a two-stage spectral clustering technique to windowed FC correlations for identifying the potential covariant structures during the spontaneous fluctuation of hippocampal-cortical FC. The obtained covariant structures were believed to be functionally homogeneous by coupling with whole-brain regions in all transient connectivity states and consequently subdivided the left and right hippocampus into six and five functional subregions, respectively. Further, we demonstrated that this dynamic-FC-derived hippocampal parcellation exhibited significantly improved reproducibility of segmented subregions across subjects compared with static FC analysis. The findings extend our understanding to the functional organization within the hippocampus and provide a more comprehensive view of the functional flexibility of the hippocampus over time.
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