Insulin Resistance in Adults with Type 1 Diabetes is Associated with Lower Vitamin D Serum Concentration

内科学 医学 胰岛素抵抗 内分泌学 1型糖尿病 维生素D缺乏 维生素D与神经学 糖尿病 胰岛素 胃肠病学
作者
Mikołaj Kamiński,Aleksandra Uruska,Anita Rogowicz‐Frontczak,Dawid Lipski,Paweł Niedźwiecki,Olga Różańska,Paulina Skonieczna,Anna Michalska,Justyna Flotyńska,Aleksandra Araszkiewicz,Paweł Uruski,Regina Pawlak,Dorota Zozulińska‐Ziółkiewicz
出处
期刊:Experimental and Clinical Endocrinology & Diabetes [Thieme Medical Publishers (Germany)]
卷期号:129 (05): 396-402 被引量:8
标识
DOI:10.1055/a-0895-5166
摘要

Abstract Aim Type 1 diabetes mellitus (T1DM) is a disease characterized by an absolute deficiency of endogenous insulin secretion. Insulin resistance (IR) may develop among patients with T1DM. Vitamin D deficiency was reported to be a risk factor in the development of IR. The aim of the study was to assess the relationship between serum concentrations of 25-hydroxyvitamin D (25(OH)D) and IR among patients with T1DM. Methods The test group consisted of 110 adult patients [males=65 (59%)] with T1DM. Participants were recruited in Poland between 1st October and 30th April in 2015/2016 and 2016/2017. VD serum level was assessed by ELISA array. IR was assessed by estimated Glucose Disposal Rate (eGDR). Results In the study group 21 (19%) patients were recognized as IR according to eGDR cut-offs (<7.5 mg/kg/min), 52 (47.3%) patients had VD deficiency (25(OH)D<20 ng/ml), 16 (14.5%) patients had 25(OH)D<10 ng/ml. Only 6 (5%) participants reported VD supplementation. Patients with IR, according to eGDR cut-off revealed significantly lower 25(OH)D serum level 15.7 (9.2–28.4) vs. 22.1 (13.0–38.4) ng/ml; p=0.04 as compared to patients without IR. R Spearman analysis found a positive relationship between VD and eGDR (Rs=0.27; p<0.01). Logistic regression analysis revealed significant relationship between the presence of IR and VD serum level/presence of 25(OH)D serum level below 10 ng/ml, both models adjusted to sex, age, BMI, LDL and triglycerides, accordingly (OR=0.95, CI: 0.90–0.99; p=0.04) and (OR=4.19, CI: 1.04–16.93; p=0.04). Conclusion The serum concentration of Vitamin D is negatively associated with insulin resistance in patients with T1DM and may have clinical implications.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
3秒前
拟岸发布了新的文献求助30
3秒前
赵一谋完成签到 ,获得积分10
6秒前
王正浩发布了新的文献求助10
6秒前
淡然以蓝完成签到 ,获得积分10
6秒前
Akim应助TINASURE采纳,获得10
6秒前
123456完成签到,获得积分10
6秒前
genhao7完成签到,获得积分10
7秒前
ei123应助慈祥的巧曼采纳,获得30
7秒前
香辣脆皮坤完成签到,获得积分10
9秒前
10秒前
苇一发布了新的文献求助20
10秒前
深情安青应助哈哈哈采纳,获得10
10秒前
失眠友灵完成签到,获得积分20
13秒前
典雅的鸡完成签到,获得积分10
13秒前
长情的冬瓜完成签到,获得积分10
16秒前
早睡发布了新的文献求助10
16秒前
顺心的皮卡丘完成签到 ,获得积分10
17秒前
17秒前
mmgf完成签到,获得积分10
18秒前
tyx完成签到,获得积分20
19秒前
小恐龙完成签到,获得积分10
19秒前
19秒前
19秒前
Lyy1208885487发布了新的文献求助10
22秒前
22秒前
TINASURE发布了新的文献求助10
23秒前
23秒前
NexusExplorer应助tyx采纳,获得10
24秒前
elmacho完成签到 ,获得积分10
24秒前
思源应助就学一点点采纳,获得10
24秒前
迟早year完成签到,获得积分10
25秒前
杨安安发布了新的文献求助10
25秒前
28秒前
li发布了新的文献求助10
28秒前
29秒前
29秒前
29秒前
31秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3966615
求助须知:如何正确求助?哪些是违规求助? 3512055
关于积分的说明 11161483
捐赠科研通 3246880
什么是DOI,文献DOI怎么找? 1793552
邀请新用户注册赠送积分活动 874482
科研通“疑难数据库(出版商)”最低求助积分说明 804420