Identification of an Oxalamide Ligand for Copper‐Catalyzed C−O Couplings from a Pharmaceutical Compound Library

Abstract A typical pharmaceutical compound library is stocked with molecular diversity and could provide a platform for the discovery of new ligand structures. Herein, we describe the use of this approach in combination with high throughput screening to identify N , N’ ‐bis(thiophene‐2‐ylmethyl)oxalamide as a ligand that is generally effective for copper‐catalyzed C−O cross‐couplings to prepare both biarylethers as well as phenols under mild conditions.