牛痘病毒
牛痘
环戊烯酮
猴痘
化学
牛痘
病毒学
天花病毒
立体化学
生物
组合化学
生物化学
重组DNA
基因
作者
Yipeng Jin,Peng Liu,Jianbo Wang,R. L. Baker,John W. Huggins,Chung K. Chu
摘要
Highly efficient and practical methodology for the syntheses of D- and l-4,5-O-isopropylidene-2-cyclopentenone (9 and 22), versatile intermediates for the synthesis of carbocyclic nucleosides, have been developed via a ring-closing metathesis reaction from d-ribose in eight steps. The utility of D- and l-4,5-O-isopropylidene-2-cyclopentenone is demonstrated by their application for the preparation of D-cyclopentyl-6-azauridine 12 and D-cyclopentenyl-5-halocytosine nucleosides (33-35) using Mitsunobu reaction to introduce pyrimidine bases as potential antiviral agents. Preliminary antiviral activity against orthopox viruses (smallpox, monkeypox, and cowpox virus) of the synthesized nucleosides are described.
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