间充质干细胞
细胞生长
细胞周期
干细胞
细胞
生物安全
材料科学
纳米颗粒
氧化铁纳米粒子
细胞生物学
细胞内
纳米技术
癌症研究
化学
医学
生物
生物化学
生物技术
作者
Dongming Huang,Jong‐Kai Hsiao,Ying‐Chun Chen,Li‐Ying Chien,Ming Yao,Yin‐Kai Chen,Bor‐Sheng Ko,Szu-Chun Hsu,Lin‐Ai Tai,Huiying Cheng,Shih‐Wei Wang,Chung‐Shi Yang,Yee‐Chun Chen
出处
期刊:Biomaterials
[Elsevier]
日期:2009-04-09
卷期号:30 (22): 3645-3651
被引量:314
标识
DOI:10.1016/j.biomaterials.2009.03.032
摘要
Superparamagnetic iron oxide (SPIO) nanoparticles are very useful in cell imaging; meanwhile, however, biosafety concerns associated with their use, especially on therapeutic stem cells, have arisen. Most studies of biosafety issues focus on whether the nanoparticles have deleterious effects. Here, we report that Ferucarbotran, an ionic SPIO, is not toxic to human mesenchymal stem cells (hMSCs) under the conditions of these experiments but instead increases cell growth. Ferucarbotran-promoted cell growth is due to its ability to diminish intracellular H2O2 through intrinsic peroxidase-like activity. Also, Ferucarbotran can accelerate cell cycle progression, which may be mediated by the free iron (Fe) released from lysosomal degradation and involves the alteration of Fe on the expression of the protein regulators of the cell cycle.
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