Association of virus infected-T cell in severe hepatitis caused by primary Epstein-Barr virus infection

单核细胞增多症 黄疸 病毒学 免疫学 病毒 爱泼斯坦-巴尔病毒感染 肝炎 爱泼斯坦-巴尔病毒 医学 乙型肝炎病毒 CD8型 免疫系统 胃肠病学
作者
Shinya Hara,Yo Hoshino,Takehito Naitou,Kei Nagano,Masakatsu Iwai,Kazuyuki Suzuki,Kazuhide Yamamoto,Tetsuro Nagasaka,Tsuneo Morishima,Hiroshi Kimura
出处
期刊:Journal of Clinical Virology [Elsevier]
卷期号:35 (3): 250-256 被引量:31
标识
DOI:10.1016/j.jcv.2005.07.009
摘要

Infectious mononucleosis owing to primary Epstein-Barr virus (EBV) infection sometimes causes hepatitis, which is usually self-limiting with mildly elevated transaminases, but can rarely develop into severe hepatitis with jaundice. To clarify the pathogenesis of severe hepatitis by primary EBV infection. We experienced four cases of severe hepatitis with jaundice caused by primary EBV infection. These cases were analyzed virologically and histologically, and compared with infectious mononucleosis patients without jaundice. Using real-time PCR, more EBV-DNA was detected in peripheral blood from patients with severe hepatitis, as compared to those without jaundice. Furthermore, CD3+, CD4+ or CD8+ cells contained more EBV DNA than did other cell populations, indicating that in severe hepatitis, T cells harbor most of the EBV. By contrast, mainly B cells were infected in infectious mononucleosis patients without jaundice. The liver was biopsied in three of the four cases. An in situ hybridization study showed that EBV infected lymphocytes, not hepatocytes. In addition, in one patient, it was confirmed that the infected lymphocytes were CD8+ T cells. These results suggest that a large EBV burden and T cell infection may play major roles in the mechanism of severe hepatitis caused by primary EB virus infection.
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