Palladium-Catalyzed Decarboxylative Arylation of C−H Bonds by Aryl Acylperoxides

A Pd(OAc)2-catalyzed protocol for decarboxylative arylation of aromatic C−H bond was developed using aryl acylperoxides as inexpensive aryl sources. Substrates containing pyridyl, oxime, and oxazoline groups undergo effectively ortho-selective C−H arylation with excellent functional group tolerance. This arylation should begin by directing-group-assisted cyclopalladation, followed by the reaction of the palladacycle with aryl radicals generated in situ by thermal decomposition of the peroxides.