电压依赖性阴离子通道
细胞生物学
线粒体
程序性细胞死亡
胞浆
生物
细胞色素c
细胞器
细菌外膜
细胞内
线粒体凋亡诱导通道
化学
细胞凋亡
生物物理学
细胞
离子通道
功能(生物学)
膜电位
自噬
生物化学
大肠杆菌
基因
酶
作者
Varda Shoshan‐Barmatz,Adrian Israelson,Dieter Brdiczka,Shey Shing Sheu
标识
DOI:10.2174/138161206777585111
摘要
Research over the last decade has extended the prevailing view of mitochondria to include functions well beyond the critical bioenergetics role in supplying ATP. It is now recognized that mitochondria play a crucial role in cell signaling events, inter-organelle communication, aging, many diseases, cell proliferation and cell death. Apoptotic signal transmission to the mitochondria results in the efflux of a number of potential apoptotic regulators to the cytosol that trigger caspase activation and lead to cell destruction. Accumulating evidence indicates that the voltagedependent anion channel (VDAC) is involved in this release of proteins via the outer mitochondrial membrane. VDAC in the outer mitochondrial membrane is in a crucial position in the cell, forming the main interface between the mitochondrial and the cellular metabolisms. VDAC has been recognized as a key protein in mitochondria-mediated apoptosis since it is the proposed target for the pro- and anti-apoptotic Bcl2-family of proteins and due to its function in the release of apoptotic proteins located in the inter-membranal space. The diameter of the VDAC pore is only about 2.6-3 nm, which is insufficient for passage of a folded protein like cytochrome c. New work suggests pore formation by homooligomers of VDAC or hetero-oligomers composed of VDAC and pro-apoptotic proteins such as Bax or Bak. This review provides insights into the central role of VDAC in cell life and death and emphasizes its function in the regulation of mitochondria- mediated apoptosis and, thereby, its potential as a rational target for new therapeutics. Keywords: VDAC, Porin, Apoptosis, Hexokinase, Cell death, Mitochondria, Ruthenium red
科研通智能强力驱动
Strongly Powered by AbleSci AI