Prevalence and related factors of chronic kidney disease (CKD) among long-lived individuals (LLI) over 95 years of age

CKD, a functional decline or break down of kidney, has been increasingly recognized as a public health problem and a predictor of poor outcomes (i.e., cardiovascular disease, dementia) and mortality among general populations. However, little is known regarding the prevalence and related factors of CKD among Chinese LLI over 95 years of age. We used data of LLI from the Rugao longevity cohort, a population-based association study conducted in Rugao, a longevity town of China. CKD was defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2. Demographic exposures and biochemical markers were correlated with CKD. The prevalence of CKD among LLI in Rugao is 23.8%. Traditional risk factors for CKD among general population, such as hypertension, diabetes, and dyslipidemia, did not have associations with CKD. However, overweight, central adiposity, and hyperuricemia were associated with increased risk of CKD, with crude odds ratios of 2.41 (95% CI = 1.23–4.69), 2.61 (95% CI = 1.42–4.77), and 5.69 (95% CI = 2.75–11.76), respectively. In addition, higher magnesium and filtration marker β2 microglobulin (β2M) were associated with CKD, with crude odds ratios of 2.47 (95% CI = 1.38–4.43) and 16.38 (95% CI = 6.76–39.64), respectively. We observe a high prevalence and unique related factors of CKD among the LLI in Rugao, which suggest that early screening and risk intervention of CKD are imperative to maintain a high quality of life and postpone the occurrence of poor outcomes.