脂质体
膜
癌细胞
生物物理学
小泡
化学
渗透(战争)
细胞膜
细胞
体内
组织工程
纳米技术
细胞生物学
材料科学
癌症
生物化学
生物
工程类
生物技术
遗传学
运筹学
作者
Junsung Lee,Jiyoung Kim,Moonkyoung Jeong,Hyoungjin Lee,Unbyeol Goh,Hyaeyeong Kim,Byungji Kim,Ji‐Ho Park
出处
期刊:Nano Letters
[American Chemical Society]
日期:2015-03-31
卷期号:15 (5): 2938-2944
被引量:154
摘要
Natural membrane vesicles (MVs) derived from various types of cells play an essential role in transporting biological materials between cells. Here, we show that exogenous compounds are packaged in the MVs by engineering the parental cells via liposomes, and the MVs mediate autonomous intercellular migration of the compounds through multiple cancer cell layers. Hydrophobic compounds delivered selectively to the plasma membrane of cancer cells using synthetic membrane fusogenic liposomes were efficiently incorporated into the membrane of MVs secreted from the cells and then transferred to neighboring cells via the MVs. This liposome-mediated MV engineering strategy allowed hydrophobic photosensitizers to significantly penetrate both spheroids and in vivo tumors, thereby enhancing the therapeutic efficacy. These results suggest that innate biological transport systems can be in situ engineered via synthetic liposomes to guide the penetration of chemotherapeutics across challenging tissue barriers in solid tumors.
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