作者
Hye Sun Kuehn,Weiming Ouyang,Bernice Lo,Elissa K. Deenick,Julie E. Niemela,Danielle T. Avery,Jean-Nicolas Schickel,Dat Q. Tran,Jennifer Stoddard,Yu Zhang,David M. Frucht,Bogdan Dumitriu,Phillip Scheinberg,Les Folio,Cathleen Frein,Susan Price,Christopher Koh,Theo Heller,Christine M. Seroogy,Anna Huttenlocher,V. Koneti Rao,Helen C. Su,David E. Kleiner,Luigi D. Notarangelo,Yajesh Rampertaap,Kenneth N. Olivier,Joshua McElwee,Jason D. Hughes,Stefania Pittaluga,João Bosco Oliveira,Eric Meffre,Thomas A. Fleisher,Steven M. Holland,Michael J. Lenardo,Stuart G. Tangye,Gülbû Uzel
摘要
Beware of T cells that don't know how to stop During an infection, T cells divide extensively and secrete proteins that can severely damage tissues. But T cells know when to stop—they express proteins on their surface such as CTLA4, which put on the brakes. Kuehn et al. now report genetic evidence of the importance of CTLA4 in humans (see the Perspective by Rieux-Laucat and Casanova). They identified six patients with mutations in one copy of CTLA4 . Patients presented with symptoms of an overzealous immune response, with immune cells infiltrating their organs. The findings support the idea that CTLA4 tells the immune system when enough is enough. Science , this issue p. 1623 ; see also p. 1560