少关节炎
多发性关节炎
医学
关节炎
优势比
人类白细胞抗原
免疫学
葡萄膜炎
HLA-B27
遗传倾向
内科学
疾病
抗原
作者
Masakatsu Yanagimachi,Takako Miyamae,Takuya Naruto,Takuma Hara,Masako Kikuchi,Ryoki Hara,Tomoyuki Imagawa,Masaaki Mori,Tetsuji Kaneko,Hiroaki Goto,Satoshi Morita,Nobuhisa Mizuki,Akinori Kimura,Shumpei Yokota
摘要
Juvenile idiopathic arthritis (JIA) is one of the most common forms of pediatric chronic arthritis. JIA is a clinically heterogeneous disease. Therefore, the genetic background of JIA may also be heterogeneous. The aim of this study was to investigate associations between human leukocyte antigen (HLA) and susceptibility to JIA and/or uveitis, which is one of the most devastating complications of JIA. A total of 106 Japanese articular JIA patients (67 with polyarthritis and 39 with oligoarthritis) and 678 healthy controls were genotyped for HLA-A, -B and -DRB1 by PCR-sequence-specific oligonucleotide probe methodology. HLA-A*02:06 was the risk factor for JIA accompanied by uveitis after adjustment for clinical factors (corrected P-value <0.001, odds ratio (OR) 11.7, 95% confidence interval (CI) 3.2–43.0). On the other hand, HLA-DRB1*04:05 was associated with polyarticular JIA (corrected P-value <0.001, OR 2.9, 95% CI 1.7–4.8). We found an association of HLA-A*02:06 with susceptibility to JIA accompanied by uveitis, which might be considered a separate clinical JIA entity. We also found an association between HLA-DRB1*04:05 and polyarticular JIA. Thus, clinical subtypes of JIA can be classified by the presence of the specific HLA alleles, HLA-A*02:06 and DRB1*04:05.
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