亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Coordination of entorhinal–hippocampal ensemble activity during associative learning

内嗅皮质 海马结构 神经科学 海马体 召回 心理学 内容寻址存储器 情景记忆 联想学习 计算机科学 认知心理学 认知 人工神经网络 人工智能
作者
Ken Igarashi,Li Lu,Laura Lee Colgin,May‐Britt Moser,Edvard I Moser
出处
期刊:Nature [Nature Portfolio]
卷期号:510 (7503): 143-147 被引量:364
标识
DOI:10.1038/nature13162
摘要

Simultaneous recordings from hippocampus and entorhinal cortex in rats show that as the animals learn odour guidance cues during their exploration of two-dimensional space in the laboratory, ensembles of coherently firing neurons emerge in both locations, with cortical–hippocampal oscillatory coupling occurring in a specific range of the beta-gamma frequency band. During declarative memory formation as well as recall, communication between the hippocampus and cortex is essential. However, the contributions to learning/recall and the nature of such communications are still unknown. Here, Edvard Moser and colleagues simultaneously record from hippocampus and entorhinal cortex to unpack the synchronicity and contributions of these two sites to memory management related to navigational behaviour. As rats learn odour guidance cues during their exploration of space, ensembles of coherently firing neurons emerged in both locations, with cortical–hippocampal coupling occurring with a specific range of the gamma oscillation. Thus, associative learning tasks seem to utilize gamma synchronization as a mechanism for maintaining evolving representations in dispersed neural circuits. Accumulating evidence points to cortical oscillations as a mechanism for mediating interactions among functionally specialized neurons in distributed brain circuits1,2,3,4,5,6. A brain function that may use such interactions is declarative memory—that is, memory that can be consciously recalled, such as episodes and facts. Declarative memory is enabled by circuits in the entorhinal cortex that interface the hippocampus with the neocortex7,8. During encoding and retrieval of declarative memories, entorhinal and hippocampal circuits are thought to interact via theta and gamma oscillations4,6,8, which in awake rodents predominate frequency spectra in both regions9,10,11,12. In favour of this idea, theta–gamma coupling has been observed between entorhinal cortex and hippocampus under steady-state conditions in well-trained rats12; however, the relationship between interregional coupling and memory formation remains poorly understood. Here we show, by multisite recording at successive stages of associative learning, that the coherence of firing patterns in directly connected entorhinal–hippocampus circuits evolves as rats learn to use an odour cue to guide navigational behaviour, and that such coherence is invariably linked to the development of ensemble representations for unique trial outcomes in each area. Entorhinal–hippocampal coupling was observed specifically in the 20–40-hertz frequency band and specifically between the distal part of hippocampal area CA1 and the lateral part of entorhinal cortex, the subfields that receive the predominant olfactory input to the hippocampal region13. Collectively, the results identify 20–40-hertz oscillations as a mechanism for synchronizing evolving representations in dispersed neural circuits during encoding and retrieval of olfactory–spatial associative memory.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
4秒前
9秒前
42秒前
1分钟前
疯狂的自行车完成签到,获得积分20
1分钟前
Akim应助科研通管家采纳,获得10
1分钟前
我睡觉不会困12138完成签到 ,获得积分10
2分钟前
脑洞疼应助xiongdi521采纳,获得10
2分钟前
阿泽完成签到 ,获得积分10
2分钟前
疯狂的自行车关注了科研通微信公众号
2分钟前
kohu完成签到,获得积分10
2分钟前
2分钟前
kohu发布了新的文献求助10
3分钟前
3分钟前
正直的松鼠完成签到 ,获得积分10
3分钟前
核桃发布了新的文献求助10
4分钟前
Xw关闭了Xw文献求助
4分钟前
4分钟前
Xw关闭了Xw文献求助
5分钟前
5分钟前
Swear完成签到 ,获得积分10
5分钟前
勤恳冰淇淋完成签到 ,获得积分10
5分钟前
5分钟前
El发布了新的文献求助10
5分钟前
5分钟前
李健应助El采纳,获得10
5分钟前
义气雁完成签到 ,获得积分10
6分钟前
6分钟前
xiongdi521发布了新的文献求助10
6分钟前
美罗培南完成签到 ,获得积分10
6分钟前
lige完成签到 ,获得积分10
6分钟前
6分钟前
6分钟前
二十四桥完成签到 ,获得积分10
6分钟前
直觉应助背后的鞋垫采纳,获得10
6分钟前
桦奕兮完成签到 ,获得积分10
7分钟前
Akim应助Borhan采纳,获得10
7分钟前
7分钟前
jjjjj发布了新的文献求助10
7分钟前
Liiiiiiiiii发布了新的文献求助10
7分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990075
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256369
捐赠科研通 3271016
什么是DOI,文献DOI怎么找? 1805171
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228