An Integrated Approach Combining Reaction Engineering and Design of Experiments for Optimizing Reactions

A certain number of reactions in the organic synthesis pose serious scale-up problems; on the other hand, other reactions create safety issues that must be addressed early during process development. The following work shows a statistical analysis of different reactions in terms of kinetics and phases (solid−liquid−gas). It also introduces an approach that permits a rapid identification of these sensitive reactions so that a better allocation of resources can be performed from the start of a project.