Trigeminovestibular and trigeminospinal pathways in rats: Retrograde tracing compared with glutamic acid decarboxylase and glutamate immunohistochemistry

Journal of Comparative NeurologyVolume 496, Issue 6 p. 759-772 Article Trigeminovestibular and trigeminospinal pathways in rats: Retrograde tracing compared with glutamic acid decarboxylase and glutamate immunohistochemistry Monique Diagne, Corresponding Author Monique Diagne diagne@ccr.jussieu.fr Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, UP7, 75251 Paris, FranceLaboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, EA3107, UP7, 2 Place Jussieu, case 7077, 75251 Paris Cedex 05, FranceSearch for more papers by this authorJocelyne Valla, Jocelyne Valla Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, UP7, 75251 Paris, FranceSearch for more papers by this authorChristian Delfini, Christian Delfini Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, UP7, 75251 Paris, FranceSearch for more papers by this authorCatherine Buisseret-Delmas, Catherine Buisseret-Delmas Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, UP7, 75251 Paris, FranceSearch for more papers by this authorPierre Buisseret, Pierre Buisseret Département Régulation, Développement, Diversité moléculaire, Muséum national d'Histoire naturelle, Bâtiment d'Anatomie comparée, 75005 Paris, FranceSearch for more papers by this author Monique Diagne, Corresponding Author Monique Diagne diagne@ccr.jussieu.fr Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, UP7, 75251 Paris, FranceLaboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, EA3107, UP7, 2 Place Jussieu, case 7077, 75251 Paris Cedex 05, FranceSearch for more papers by this authorJocelyne Valla, Jocelyne Valla Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, UP7, 75251 Paris, FranceSearch for more papers by this authorChristian Delfini, Christian Delfini Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, UP7, 75251 Paris, FranceSearch for more papers by this authorCatherine Buisseret-Delmas, Catherine Buisseret-Delmas Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, UP7, 75251 Paris, FranceSearch for more papers by this authorPierre Buisseret, Pierre Buisseret Département Régulation, Développement, Diversité moléculaire, Muséum national d'Histoire naturelle, Bâtiment d'Anatomie comparée, 75005 Paris, FranceSearch for more papers by this author First published: 20 April 2006 https://doi.org/10.1002/cne.20964Citations: 30Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract This study identified neurons in the sensory trigeminal complex with connections to the medial (MVN), inferior (IVN), lateral (LVN), and superior (SVN) vestibular nuclei or the spinal cord. Trigeminovestibular and trigeminospinal neurons were localized by injection of retrograde tracers. Immunohistochemical processing revealed γ-aminobutyric acid (GABA)- and glutamate-containing neurons in these two populations. Trigeminovestibular neurons projecting to the MVN and the IVN were in the caudal principal nucleus (5P), pars oralis (5o), interpolaris (5i), and caudalis (5c) and scattered throughout the rostral 5P. Projections were bilateral to the IVN, with an ipsilateral dominance to the MVN, except from the rostral 5P, which was contralateral. Neurons projecting to the LVN were numerous in the ventral caudal 5P and the 5o and less abundant in the rostral 5P, 5i, and 5c. Our results suggested that only 5P and 5o project to the dorsal LVN. Neurons projecting to the SVN were in the dorsal 5P, 5o, and 5i but not in 5c. Trigeminospinal neurons were mainly in the ventral 5o and 5i and in the lateral 5c, rarely or never in 5P. Among trigeminovestibular neurons, most of the somas were immunoreactive for glutamate, but some reacted for GABA. Among trigeminospinal neurons, the number of somas immunoreactive for each of the two amino acids was similar. Trigeminal terminals were observed in contact with vestibulospinal neurons in the IVN and LVN, giving evidence of a trigeminovestibulospinal pathway. Therefore, inhibitory and excitatory facial inputs may contribute through trigeminospinal or trigeminovestibulospinal pathways to the control of head/neck movements. J. Comp. Neurol. 496:759–772, 2006. © 2006 Wiley-Liss, Inc. Citing Literature Volume496, Issue620 June 2006Pages 759-772 RelatedInformation