自愈水凝胶
流变学
纤维蛋白
动力学
浊度
材料科学
纤维蛋白原
动态力学分析
蠕动
弹性模量
剪切模量
化学工程
复合材料
化学
高分子化学
聚合物
地质学
生物化学
海洋学
物理
量子力学
工程类
免疫学
生物
作者
Jennifer Wedgwood,Anthony J. Freemont,Nicola Tirelli
标识
DOI:10.1002/masy.201300111
摘要
Summary Fibrin hydrogels prepared from different fibrinogen concentrations (12.5, 25 and 50 mg/mL) were studied through oscillatory rheology (gelation kinetics, stress amplitude tests and frequency sweeps), static experiments (creep and recovery tests) and turbidity (gelation kinetics). The experimental parameters obtained from these measurements (including gel point, characteristic times for different kinetic phases, loss and storage moduli), were used to gain some insight on the processes concurring to form the network structure of fibrin hydrogels. Here, we show (turbidity measures) that lateral fibre aggregation appears to be significantly depressed with increasing fibrinogen concentration. Among other important findings, a caveat in using absolute data of mechanical properties from gelation kinetics: we have shown that at low fibrinogen concentration, the actual modulus values are significantly affected by the application of shear stress during gelation.
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