熊果酸
化学
过氧化物酶体增殖物激活受体
兴奋剂
生物化学
脂质代谢
受体
肝X受体
过氧化物酶体
交易激励
核受体
基因表达
转录因子
基因
色谱法
作者
Yaoyao Jia,Muhammad Javidul Haque Bhuiyan,Hee‐jin Jun,Ji Hae Lee,Minh Hien Hoang,Hak-Ju Lee,Nahyun Kim,Dongho Lee,Kwang Yeon Hwang,Bang Yeon Hwang,Dal-Woong Choi,Sung‐Joon Lee
标识
DOI:10.1016/j.bmcl.2011.07.095
摘要
In this study, we confirmed that ursolic acid, a plant triterpenoid, activates peroxisome proliferator-activated receptor (PPAR)-α in vitro. Surface plasmon resonance and time-resolved fluorescence resonance energy transfer analyses do not show direct binding of ursolic acid to the ligand-binding domain of PPAR-α; however, ursolic acid enhances the binding of PPAR-α to the peroxisome proliferator response element in PPAR-α-responsive genes, alters the expression of key genes in lipid metabolism, significantly reducing intracellular triglyceride and cholesterol concentrations in hepatocytes. Thus, ursolic acid is a PPAR-α agonist that regulates the expression of lipid metabolism genes, but it is not a direct ligand of PPAR-α.
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