生物
RNA剪接
遗传学
拼接因子
RNA结合蛋白
保守序列
信使核糖核酸
细胞生物学
肽序列
核糖核酸
基因
作者
J. Andrew Berglund,Katrin F. Chua,Nadja Abovich,Robin Reed,Michael Rosbash
出处
期刊:Cell
[Elsevier]
日期:1997-05-01
卷期号:89 (5): 781-787
被引量:323
标识
DOI:10.1016/s0092-8674(00)80261-5
摘要
The yeast splicing factor BBP (branchpoint bridging protein) interacts directly with pre-mRNA at or very near the highly conserved branchpoint sequence UACUAAC within the commitment complex. We also show that the recombinant protein recognizes the UACUAAC sequence. Therefore, BBP is also an acronym for branchpoint binding protein. The mammalian splicing factor SF1 is a BBP ortholog (mBBP) and an E complex component, and also has branchpoint sequence specificity. The relative conservation of this region in yeast and mammals correlates well with the RNA-binding differences between BBP and mBBP, suggesting that BBP contributes to branchpoint sequence definition in both systems.
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