CRY links the circadian clock and CREB-mediated gluconeogenesis

Circadian oscillators based on a transcriptional feedback loop exist in almost all cells of animals. The cellular oscillators synchronize each other via paracrine or systemic communications, resulting in rhythmic changes of tis-sue- and whole body-level physiologies and behaviors. Circadian regulation of metabolism is well documented and disruption of such temporal regulation is known to predispose organisms to metabolic diseases. However, the under-lying mechanism of circadian regulation of metabolism is complex and incom-pletely understood. The research has mainly focused on the transcriptional mechanisms by which circadian clock components regulate metabolic gene expression. A recent paper by Zhang