化学
酰胺
效力
离体
体内
立体化学
结构-活动关系
体外
生物化学
生物
遗传学
作者
Scott P. Webster,Peter Ward,Margaret Binnie,Eilidh Craigie,Kirsty M.M. McConnell,Karen Sooy,Andy Vinter,Jonathan R. Seckl,Brian R. Walker
标识
DOI：10.1016/j.bmcl.2007.02.057
摘要
A series of adamantyl amide 11β-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11β-HSD1 over 11β-HSD2 and possess excellent cellular potency in human and murine 11β-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.
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