医学
危险系数
髋部骨折
胱抑素C
肾功能
内科学
置信区间
肾脏疾病
比例危险模型
队列研究
队列
骨质疏松症
外科
作者
Linda F. Fried,Mary Biggs,Michael G. Shlipak,Stephen L. Seliger,Bryan Kestenbaum,Catherine Stehman‐Breen,Mark J. Sarnak,David S. Siscovick,Tamara Harris,Jane A. Cauley,Anne B. Newman,John A. Robbins
出处
期刊:Journal of The American Society of Nephrology
日期:2006-12-14
卷期号:18 (1): 282-286
被引量:206
标识
DOI:10.1681/asn.2006050546
摘要
The effect of loperamide and naloxone on mouth-to-caecum transit time was evaluated by the lactulose hydrogen breath test in four men and four women. Each subject underwent tests during the administration of placebo, loperamide (12-16 mg po), naloxone (40 micrograms/kg/h by a three-hour intravenous infusion), and loperamide plus naloxone, carried out at intervals of one or two weeks. The transit time was significantly longer after loperamide, and this effect was antagonised by the concomitant administration of naloxone whereas naloxone administered alone had no effect on mean transit time. No clinically important side effects were reported.
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